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Those factors can influence the extent to which 5-MTHF, available inside cells, will be used for methylation reactions and DNA synthesis.32,33 Mitochondrial Metabolism Related to AdCbl Inside the mitochondria, a portion of available cobalamin is converted to AdCbl, a cofactor for the conversion of methylmalonyl CoA (MMCoA) to succinyl-CoA, which enters the Krebs cycle