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Dec 2015;110(3):e13-17

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Wiener RC, Wu B, Crout R, Wiener M, Plassman B, Kao E, McNeil D

The steric hindrance introduced by the brush-like PEG molecules from the surface of the nanoparticles can result in prolonged residence time in the circulation of the nanoparticles, and potential accumulation to specific tissues, such as tumors, due to the enhanced permeation and retention effect (EPR) (Lahooti et al., 2023)

Logically, cationic LNPs should be able to complex RNA in a similar manner to polyplexes, which have been shown to protect RNA from degradation by complexation and condensation, despite the RNA being exposed on the surface of the complex [17, 23]