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Elmore, ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

Intermittent and short-term reoxygenation help prevent the remodeling of pulmonary artery function and structure, as well as the proliferation, migration, and phenotypic transformation of pulmonary artery smooth muscle cells in hypoxic conditions, thus effectively reducing hypoxia-induced pulmonary hypertension [91]

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Pioneering clinical work has demonstrated the potential of this approach: in a landmark trial, a blind patient expressing ChrimsonR in RGCs regained partial light perception after training with engineered goggles that converted visual scenes into optogenetic stimuli [221]