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Philippe, and J

While some benefits have been observed in several studies for the various diseases and conditions discussed here, the side effects associated with anti-VEGF or anti-VEGFR-2 therapies can be severe and include heightened risk of arterial thromboembolic events, hypothyroidism, wound healing complications, GI perforations, neutropenia and hematological effects and increased risks for other cardiac adverse events (245, 247249)

PubMed, Hu, Qingting, et al

It is also important to consider the potential for interactions with chemotherapeutic agents

Perineuronal nets are extracellular matrix structures that are important for synaptic stabilization and plasticity, especially during development, and are involved in functional recovery after lesions and play key roles in interactions between nerve processes and astrocytes in the CNS (6668)