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Cardiovascular and metabolic screening is frequently wise
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Administration of finasteride, a specific 5 -reductase-2 inhibitor causes a selective decrease in both circulating and intraprostatic DHT, a significant decrease in prostate size due to prostatic cell apoptosis 64 , 65 , and an improvement of clinical symptoms in BPH 66

They also report restoration of melatonin secretion in aged humans and monkeys, with effects on circadian rhythm

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