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Conflict of interest The authors declare no conflict of interest

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In line with the UKB cohort data (ESM Table 9), vitamin B 12 deficiency was more prevalent in the AA genotype group treated with metformin vs GG (OR 2.17 [95% CI 1.80, 2.60]

Importance of Accurate Measurement and Sterile Handling Accurate measurement is critical when working with GHK-CU, as even small deviations can affect research outcomes or formulation stability
