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Published Research on 5-Amino-1MQ Foundational DIO Mouse Study Neelakantan et al., Biochemical Pharmacology (2018) This paper introduced 5-Amino-1MQ as a selective and membrane-permeable small molecule inhibitor of NNMT and tested it in 3T3-L1 adipocytes and in male C57BL/6J mice maintained on a high-fat diet

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Results Three independent clinical studies of women (i) non-pregnant at child-bearing age, (ii) in early pregnancy, and (iii) at delivery showed that low vitamin B 12 status was associated with higher total cholesterol, LDL cholesterol, and cholesterol-to-HDL ratio