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Compared with normal animals, Nrf2-deficient mice have more pronounced effects on lipopolysaccharide (LPS)-induced microglial activation and inflammatory response, with lower levels of IL-1, IL-6, IL-12, and TNF- in the brain ( Moreover, increasing evidence indicated that Nrf2 may regulate mitochondrial function and metabolism

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The morphological features of ferroptosis primarily involve mitochondrial alterations including rupture of the mitochondrial membrane, reduced mitochondrial size with increased mitochondrial membrane densities, and loss of mitochondrial cristae (Li J

Blood Adv 6:59805994 Ignacio A, Shah K, Bernier-Latmani J, Koller Y, Coakley G, Moyat M, Hamelin R, Armand F, Wong NC, Ramay H et al (2022) Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization