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(P-gp and other members of the MDR family are also found in the blood-brain barrier and in drug-resistant cancer cells.) Drugs that inhibit intestinal P-gp mimic drug metabolism inhibitors by increasing bioavailability
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While synthetic human growth hormone (HGH) can be effective, it's expensive, suppressive, and banned in nearly every sport
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Additionally, PUMA triggers an intrinsic apoptosis pathway associated with colitis