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The NRG CC001 trial established that hippocampal-avoidance WBRT (HA-WBRT) combined with memantine better preserves NCF and quality of life compared to conventional WBRT (32, 33)

The intermediate form of the enzyme is further reduced by the formation of an intra-molecular disulfide bond between the two active site cysteines, leaving the enzyme in an oxidized form, from which the vicinal thiols are regenerated by the FAD(H)-intermediated hydride transfer from NAD(P)H

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However, these biological differences are not validated, adoptable, accurate, or specific enough for a diagnostic application

WirnitzerKCMotevalliMCoccaATanousDRWirnitzerGWagnerKHet al