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Postinflammatory hyperpigmentation: a comprehensive overview: treatment options and prevention

Finally, supplementing NaGYY, the sodium salt of GYY4137, a slow-releasing H 2 S donor, restored sulfhydration and ameliorated motor and cognitive deficits in the 3xTg-AD mice (Giovinazzo et al., Figure 2 Therapeutic Avenues Analysis of clinical trials conducted so far, reveal a preference for non-amyloid targets, which include therapeutics targeting inflammation, synapse and neuronal protection, vascular factors, neurogenesis, and epigenetic modifications (Cummings et al., 2 S regulates a wide array of neuroprotective processes, therapies, and interventions involving either the use of H 2 S delivering drugs or agents which stimulate its production are gaining importance

Hence, the application of nanotechnology could enhance the efficacy and improve their bioavailability by increasing solubility, enhancing plasma half-life, preventing degradation in the intestinal environment, and elevating permeation in the small intestine (Hu et al., 2017)

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