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however, the mechanisms underlying their protective effects remain unclear

1,6,7,12,132 When blood pressure control is suboptimal, additional medications such as calcium channel blockers, non-selective beta-blockers (with carvedilol or propranolol being the primary choices for patients with clinically significant portal hypertension to prevent esophageal variceal bleeding), and thiazide diuretics may be added

COX-2 and 5-LOX enzyme inhibitors can hinder the synthesis of prostaglandins and leukotrienes

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In the TASCC, autophagy degrades proteins into small molecules, such as amino acids, and these amino acids activate mTOR to induce the synthesis of various cytokines, chemokines, etc