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This contributes to $6 billion spent yearly on gallstone-related treatments

January 2013;216(1):4351

Ann Endocrinol

Several enzymes necessary for glycolysis (glucose-6-phosphate isomerase), lactate formation (lactate dehydrogenase, malate dehydrogenase), plus an enzyme of the oxidative branch of the pentose phosphate pathway (transketolase), an enzyme of glutamine metabolism (glutamate dehydrogenase 1) and an enzyme of fatty acid synthesis (acetyl-CoA carboxylase-) were found in the composition of ATP-stimulated exosomes

The introduction of wild-type and SPX-deleted XPR1 , which lacks inositol pyrophosphate binding region, a SPX domain, of this transporter with unmodified transmembrane regions, increased the export of 32 P activity and decreased intracellular 32 P activity (Fig