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AACE Clin Case Rep

The brain is especially vulnerable to the effects of alcohol, as it rapidly diffuses through the bloodbrain barrier and alters neurotransmission

Additionally, gene set enrichment analysis confirmed that ferroptosis was positively related to GSH treatment (Fig

The lactate shuttle hypothesis further revealed its pivotal roles in oxidative substrate transport and cellular signaling via monocarboxylate transporters (MCTs), leading to its recognition as a potent signaling metabolite, particularly through its receptor GPR81 (6-8)

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