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Although there are several downstream degenerative events, it appears that mitochondrial dysfunction and oxidative stress are the key triggering factors in the pathogenesis of AD

doi: 10.3390/biomedicines12122801 57 SharmaS

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proposes that Hup-A modulates Ca 2+ levels through the Cdk5 activation pathway, which activates anti-apoptotic factors [207]

In addition, the energy required to break the Cu 2+ /imidazolyl coordination bond is not the lowest in comparison to Cu 2+ /carboxyl and Cu 2+ /amino coordination, leading to a negative impact on the catalytic activity also 28,29