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Alzheimers disease Alzheimer's disease (AD), the most prevalent neurodegenerative disease, is characterized by two pathological hallmarks: the aggregation of insoluble forms of amyloid (A) in extracellular plaques, as well as the deposition of neurofibrillary tangles (NFTs) made up mainly of hyperphosphorylated microtubule protein tau in neurons [9799]

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