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374 New potential pharmacological targets The abovementioned antidepressants have been utilized as clinical therapies for MDD, but it is difficult to elucidate the exact pharmacological mechanisms of every medicine due to delayed clinical efficacy, poor treatment response to some patients, and difficulty in effectively controlling the incidence of suicide

For example, the FAO inhibitor etomoxir reversed cisplatin resistance in cisplatin-resistant cells from OC and GC [57, 64], perhexiline reversed AUY922 resistance in PCa cells [51], and thiolidazine reversed enzalutamide resistance in PCa cells [155]

The worldwide incidence of AMD is anticipated to increase from 196 million cases in 2020 to 288 million cases by 2040 (216)

These criteria greatly limit the universe of potential respondents

However, several challenges remain, including low bioavailability, an incomplete understanding of their mechanisms, uncertainties about the optimal dosing regimen, and the potential interactions among different polyphenols