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545 For example, pelacarsen, an Lp(a) ASO drug developed by Ionis in collaboration with Novartis AG, effectively lowers Lp(a) levels by selectively cleaving Apo(a) gene (LPA) mRNA

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Second, it disrupts the PI3K/Akt/mTOR pathway, resulting in autophagic flow blockade and the accumulation of damaged organelles

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