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All Aspergillus allergens appear to activate a Type I hypersensitivity response in sensitized patients with production of high affinity IgG and IgE antibodies.232 In immunocompromised patients with debilitated innate immune responses, these allergenic compounds can increase the risk associated with aspergillosis because they may redirect the immune response to the fungus by the activation of Th2 lymphocytes, a response that does not seem to be efficient in eliminating this fungus.108 Some of these allergens have been studied for their usefulness for diagnosis (see Allergome1 and Table 7)

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doi: 10.1038/s41574-020-0364-6

However, such design leaves the C-terminal end of albumin free and susceptible to enzymatic cleavage by CPA