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Depletion of Cu using chelators has been shown to delay cancer metastasis by inhibiting the vascularization of lesions across several animal models, including a rabbit VX2 carcinoma model, 181 a mouse model of hepatocellular carcinoma, 182 and head and neck squamous cell carcinoma

Finally, the binding site of lumacaftor, a clinically used corrector that stabilizes unfolded CFTR, binds in the outer perimeter of NBD1 near the R-domain binding site 37

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all authors revised the manuscript