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After 5 min at 95C followed by centrifugation for 10 min at 12,000 g, 20 L of the resulting supernatant was diluted with 80 L deionized water for subsequent aldehyde determination

ONO-3411 and MK-477 have shown anti-inflammatory activity in mouse models, which appears to be exerted through COX inhibition

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Cellular metabolism alters the microenvironment via generating and/or depleting metabolites, to regulate macrophage polarization [10,11,12]