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Description
109 Patients with significant renal dysfunction will have altered phenytoin protein binding

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Clinical trials showed optimal results with 2 to 4 treatments for most patients

However, in vivo , the mechanisms driving this M1 to M2 phenotypic switch may be more complicated and may be regulated by IL-10, glucocorticoids, prostaglandins, miRNAs, and adenosine and peroxisome proliferator-activated receptor (PPAR-) signaling in the wound microenvironment (8688, 109)