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APAP toxicity, whether resulting from a single overdose or repeated supratherapeutic ingestion, progresses through four phases: preclinical toxic effects (phase one), hepatic injury (phase two), hepatic failure (phase three), and recovery (phase four)

Peer review Peer review information Nature Materials thanks Ke Cheng, Gregg Duncan and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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