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Figure 5 3.8 BI4916 and Rylaze combination decreases protein synthesis and cap-dependent mRNA translation Prior reports by our group have demonstrated that crisantaspase treatment diminishes protein synthesis in AML by interfering with cap-dependent mRNA translation downstream of mammalian target of rapamycin (mTOR) signaling, specifically by inhibiting the phosphorylation of p70 ribosomal S6 kinase (p70S6K), a key downstream effector of mTOR ( Figure 6A )

[DOI] [PMC free article] [PubMed] [Google Scholar] 255.Nawaz M., Heydarkhan-Hagvall S., Tangruksa B., Gonzlez-King Garibotti H., Jing Y., Maugeri M., et al

Connect one end of the plastic tubing to the air compressor

Consortium WHOST, Pan H, Peto R, et al

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