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A randomized, double-blind, placebo-controlled trial in 153 older adults taking the antidepressant citalopram found daily supplementation with 500 g vitamin B 12 , 2 mg of folic acid, and 25 mg of vitamin B6 for one year did not reduce the severity of depressive symptoms but increased the response to drug treatment and helped to prevent symptom relapse (112), suggesting B-vitamin supplementation might provide some benefit as an adjunct therapy

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A cell model bioassay was developed (1) to determine the bioactivity of biovaratropin, (2) to reduce the use of laboratory animal models consistent with best practices and 3Rs, (3) to supplant the aforementioned standard rat in vivo weight gain assay, and (4) to engender a simple, robust and precise bioactivity assay throughout the research, development and manufacture of biovaratropin

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An injection of B12 can bring on immediate health benefits