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About this article Cite this article Migliore, L., Copped, F
But tolerance isnt the only reason
Instead, a large number of genes encoding class III peroxidases are rapidly and greatly upregulated and peroxidase activity increases in apoplastic space 28
Most of these resolve with continued use and proper dose titration
Continuous, unending stimulation from a GHRH analogue can, over time, lead the pituitary to become less and less responsive
