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One half was fixed in formalin for histopathological analysis, whereas the other half was flash frozen

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This activation initiates a cascade of beneficial downstream effects: Increased Glucose Uptake: AMPK promotes the translocation of GLUT4 transporters to the cell membrane, particularly in skeletal muscle, enhancing the uptake of glucose from the bloodstream

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[28] found that NNMT knockdown significantly reduced the body weight, fat mass, and insulin level of female mice fed a Western diet (fat 47% kcal, carbohydrate 34% kcal), as did NNMT knockout