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Vitamin B12 deficiency can impact brain function and increase dementia risk
Berry AS, Kelly BJ, Barnhart D, Kelly DJ, Beiting DP, Baldassano RN, Redding LE

Theoretically, chronic lipolysis activation could deplete essential lipid stores or disrupt adipose tissue-derived signaling pathways (via adipokines), though this remains speculative

To support this metabolic process, some clinicians recommend co-supplementation with a methyl donor such as trimethylglycine (TMG) while on NAD+ injections
