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Downregulation of carnitine acyltransferases and organic cation transporter octn2 in mononuclear cells in healthy elderly and patients with myelodysplastic syndromes

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Downregulation of ATP5A1, the ATP Synthase F1 Subunit Alpha [123], and ATP5G3, the ATP synthase F0 complex subunit C3 [124], was observed in the postmortem study of ASD patients in all examined regions [122], which could inhibit the activity of complex V [79] and promote the ETC breakdown due to opening of the mPTP [125, 126]

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