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AMUWEC20257048) and performed in compliance with the ARRIVE guidelines and the principles of the Basel Declaration

Consistent with these in vivo effects, we found that bradykinin-stimulated production of NO was enhanced by vector-mediated GPx1 overexpression in cultured endothelial cells at baseline and in the presence of exogenous homocysteine [60]

IGF-I and IGFBP-3 levels increase slowly from birth until a more rapid increase and peak during puberty, which is followed by a decline toward low levels in senescence (50, 51) (Figure 2)

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Additionally, FSP1 catalyzes the reduction of coenzyme Q10 (CoQ 10 ) or vitamin K into their reduced forms, CoQH 2 or VKH 2 , which function as antioxidants to suppress ferroptosis [5, 15]