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Impairment of the mitochondrial one-carbon metabolism enzyme SHMT2 causes a novel brain and heart developmental syndrome

This is classically demonstrated with the consumption of vitamin D to prevent rickets, vitamin C to prevent scurvy, or folic acid to prevent neural tube defects (14)

Nat Commun 2015, 6 (1), 8101

[DOI] [PubMed] [Google Scholar] 72.Gallelli G., Cione E., Serra R., Leo A., Citraro R., Matricardi P., Di M.C., Bisceglia F., Caroleo M., Basile S., et al

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