l-carnitine tmao nature medicine 2013 koeth Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis: Cell Gut microbiota metabolism of l-carnitine
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(130) demonstrated that administering apigenin increases estradiol levels in DHEA-induced PCOS model rats, likely due to its antioxidant properties and the suppression of inflammatory cytokines such as TNF- and IL-6

Studies reveal that TMAO promotes macrophage polarization towards the M1 phenotype, characterized by enhanced production of pro-inflammatory cytokines and amplified antigen-presenting capacity

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