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Deficiency develops gradually, as the body stores approximately 2-5 mg of B12 in the liver, which can sustain normal function for several years even with inadequate intake or absorption

[DOI] [PMC free article] [PubMed] [Google Scholar] 274.Holy E.W., Stmpfli S.F., Akhmedov A., Holm N., Camici G.G., Lscher T.F., Tanner F.C

To overcome bottlenecks such as the mucus barrier, macrophage phagocytosis, and rapid mucociliary clearance, cell membrane-coated nanoparticles, exosome-based carriers, and smart nanosystems capable of sensing the pathological microenvironment and releasing drugs in response are expected

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Silymarin (SM) is a potent anti-inflammatory molecule capable of inhibiting NF-B pathways and optimizing the redox balance in the cell through activating antioxidant enzymes and non-enzymatic antioxidants via Nrf2 activation [574]