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Anxiety-like behavior can be induced in rats through intracerebroventricular streptozotocin (ICV-STZ) injections, which is accompanied by diffuse amyloid plaques in the hippocampus, enlargement of ventricles, and spine loss in the dentate gyrus (Roy et al., 2022)

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In vitro studies have shown that bile acids can regulate the expression level of angiotensin-converting enzyme 2 (ACE2) by activating the farnesoid X receptor (FXR), thereby influencing the pulmonary inflammatory response (107)