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As canonical outputs of the UPRmt, mitokines represent a pivotal transition point where mitochondrial stress signaling extends beyond organelle-level homeostasis to orchestrate whole-body metabolic regulation

For example, vitamin D induces BDNF release via calcium signaling by upregulating voltage-gated calcium channels, while folate and B vitamins are involved in neuroprotective effects through limiting neurotoxic homocysteine levels, which inhibits neurotrophic signaling [221]

Tm values were taken as the midpoint of the melting curves, found from the peak of the first derivative

The appendix can vary in size and position relative to the ileocecum, making it challenging to identify the base of the appendix, especially in the setting of acute inflammation

BPC-157 has demonstrated strong anti-inflammatory effects in clinical studies