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Although BRCA1 is infrequently mutated in sporadic TNBC, low expression or inactivation of BRCA1 may occur in wild-type TNBC due to epigenetic gene silencing, miRNA-mediated post-transcriptional suppression, and other nongenetic alterations [109,110,111]

GPX4 is the only cellular enzyme that specifically reduces phospholipid hydroperoxides to lipid alcohols using GSH as a co-factor 4 , and inhibiting the cyst(e)ine/GSH/GPX4 axis induces the strongest cell death in most cellular contexts

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Epigallocatechin Gallate Is the Most Effective Catechin Against Antioxidant Stress via Hydrogen Peroxide and Radical Scavenging Activity

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