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In yet another preferred embodiment of the invention, the CNS pathology is one of a neuropsychiatric disorders, such as depression (e.g., modified by using brain targeted liposomal mineralocorticoid receptor agonists like fludrocortisone, deoxycorticosterone or aldosterone, thereby reducing peripheral cardiovascular side- effects), autism, anxiety, attention deficit hyperactivity disorder (ADHD), addiction and other substance-related disorders, neuropsychiatric systemic lupus erythematosus, bipolar disorder, eating disorders, schizophrenia, and other psychoses

found that dysregulation of system enhances Treg function that promotes VEGF blockade resistance in glioblastoma (45)

Jones JC, Kam CY, Harmon RM, Woychek AW, Hopkinson SB, Green KJ

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Strategies to minimize plant and medication-induced nephrotoxicity include quality control and standardization of herbal/drug products, research on the pathophysiological mechanisms of toxicity and adequate clinical trials to demonstrate efficacy and safety [56]