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if further testing is required, this should be by a rheumatologist, who will look for (amongst other things) lupus, Sjogren's, connective tissue disease, rheumatoid arthritis...and many other autoimmune conditions too

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Conversely, the expression of genes encoding the tight junction proteins that maintain the BBB, namely claudin-5, occludin, ZO1/tight junction protein-1, cadherin-1, and cadherin-5 decrease initially after 5 days and decreases further by 5 weeks on a cuprizone diet