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DISCLAIMER: Our peptides can be used solely for in vitro experiments and cannot be:

(2018) 13(3):e0192664

10.1111/1751-7915.13410 240 ZhangY.LiuF.MaoY.ZengH

Glutamate transporter alterations in Alzheimer disease are possibly associated with abnormal APP expression

To explore whether targeted intervention of Chac2 in neutrophils could alleviate the inflammatory comorbidity of periodontitis, we constructed AAV9 viruses targeting neutrophils to specifically knock down Chac2 (AAV-shCHAC2) and a control virus with no payload (AAV-NC), and administered them via intraosseous injection into a mouse model with periodontitis and diabetes comorbidity