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S conformation and assembly state influence cytotoxicity such that shifting the levels of physiological -helical tetramers toward the more aggregation-prone monomers leads to S cytoplasmic inclusions, hyperphosphorylation, and neurotoxicity 42,43,51,52

Koga Y, Akita Y, Nishioka J, Yatsuga S, Povalko N, Tanabe Y