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Rani SAE, Ryan MD, Griffin T, Ritter

B.LealA

The loading phase typically uses 2-2.5mg twice weekly for 4-6 weeks, totaling 4-5mg per week

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The 3A mutation in GAP-F5 protein effectively blocks the increase in G2019S LRRK2-mediated phosphorylation in response to increasing amounts of GAP-F5 protein substrate, compared to the concentration-dependent increase in WT GAP-F5 phosphorylation, by in vitro radioactive kinase assay (Figure 2E)
