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Importantly, Mn levels are substantially lower than those of other trace elements, such as iron and zinc

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Additionally, cytokine-mediated inflammation, microglial activation, and gut dysbiosis are associated with schizophrenia onset and symptom severity

430 These findings suggest that iron metabolism is abnormal in the cells of Friedreichs Ataxia models, and regulation of iron metabolism may have some ameliorative effects on Friedreichs Ataxia
