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the program demonstrated a favorable safety profile but the Phase IIb obesity trial produced modest weight-loss effects (mean reduction in treated groups roughly 2.6 kg vs

Metabolic effects of social isolation in adult C57BL/6 mice (in Eng)

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Investigators are particularly interested in determining the mechanisms by which effects observed in murine models relate to broader mammalian metabolic regulation, and whether different experimental conditions (young vs aged models, healthy vs metabolically compromised states) show differential responses to NNMT inhibition

This is also why the first month emphasizes routine so heavily