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ROS are unstable oxygen-containing molecules that easily react with other molecules in a cell [14] and are generated after physiological dysfunctions or exposure to physical agents, such as ultraviolet rays and heat, chemical factors, environmental toxicants, smoking, alcohol, or even other factors, such as obesity, varicocele, aging, or diabetes [11]

Kim et al., Nanoparticles in 472 human cerebrospinal fluid: changes in extracellular vesicle concentration and MiR-21 expression as a biomarker for leptomeningeal metastasis

However, no conclusive data are available on its involvement in carnitine traffic under physiological conditions