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The sleep improvement is a secondary effect of restored hypothalamic-pituitary-adrenal axis function, not a direct pharmacological sedation

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The practical rationale for combination protocols is straightforward: BPC-157 targets local tissue repair (particularly GI, musculoskeletal, and neural) through signaling pathways that promote growth factor expression and cell survival at injury sites, while TB-500 operates more systemically particularly through vascular remodeling, cardiac progenitor activation, and direct anti-inflammatory cytokine modulation

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While the normal range, is typically between 138-652pmol/L, the reality is that many patients feel better if B12 levels are in the higher end of that range