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However, formal interaction studies are limited

Drug synergism was measured using the Loewe model with Combenefit software (Cancer Research UK Cambridge Institute), and the combination index was calculated using CompuSyn software (ComboSyn) ( 3 Results 3.1 CB-839 treatment inhibits glutathione synthesis and the conversion of glutamine to glutamate in CLL cell lines Initially, we investigated CB-839s functional inhibition of GLS-1 ( Figures 1A, B )

coli MG1655, respectively to construct the recombinant strains ET00 and ET01 (Table 1)

The data of comparative expression levels between genes are given on a logarithmic scale expressed as 40 C T , where C T is the difference in qRT-PCR threshold cycle number between the respective gene and the reference gene

Phosphoribosyl diphosphate (PRPP): biosynthesis, enzymology, utilization, and metabolic significance