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Alternatively, acetylcarnitine, produced in excess in mitochondria by CrAT, is transported into cytosol by CACT and enters the nucleus, where a nuclear CrAT converts the acetylcarnitine to acetyl-CoA 67 , and it becomes a source of acetyl groups for histone acetylation

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tablet, capsule or liquid) or two daily administrations (one every 12 hours) of a 120 mg extended release preparation one daily administration of a 240 mg extended release preparation