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In humans, a RCT enrolling 156 patients with a BMI 27 kg/m 2 failed to demonstrate that one year of liraglutide treatment could improve pain in patients with KOA compared to placebo, despite a significant BW difference of approximately 4 kg at end of study 105

Early dietary and lifestyle intervention should be implemented to reduce obesity and avoid post-operative deficiency and its associated side-effects

Vitamin B12 supports the nervous system by maintaining myelin, which is the protective coating around nerves

Excess oxidized low-density lipoprotein (oxLDL) in the follicular fluid of obese women increases ROS levels via NADPH oxidase, further enhancing granulosa cell autophagy (Lai et al., 2018)

Fraser et al, however, reported no resistance by patients to reducing the frequency of their injections