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Acknowledgments We thank Duke Omariba, our study coordinator and all the staff members at the MDR sentinel sites for their contribution in recruitment of participants and sample collection

Future medicinal chemistry efforts may yield next-generation compounds with enhanced properties, including improved tissue selectivity, modified pharmacokinetics, or additional mechanistic activities that complement NNMT inhibition

The SELECT trial, enrolling over 17,000 patients with established cardiovascular disease over nearly 40 months, confirmed the cardiovascular safety of semaglutide and demonstrated net benefit in a high-risk population

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