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reported that the p.Ala391Thr variant results in a complete loss of SLC39A8 protein expression, leading to a complete absence of cellular uptake of Mn 2+ and other bivalent ions

Shao JS, Aly ZA, Lai CF, Cheng SL, Cai J, Huang E, Behrmann A, Towler DA

What are the main side effects of taking berberine with L-carnitine

thus, taking in account that this kind of NP is refractory to clinical treatments, depression and suicide are very frequently (Stillman et al., 2017)

Neuropsychopharmacology 35(8):16251652
